| 2. Round | 27/11/2021 | Adelaide United | - | Melbourne City FC | 2:2 | ||||
| 10. Round | 15/01/2022 | Adelaide United | - | Melbourne City FC | 2:2 | ||||
| 22. Round | 23/01/2022 | Central Coast Mariners | - | Melbourne City FC | 1:3 | ||||
| 12. Round | 29/01/2022 | Western United | - | Melbourne City FC | 1:0 | ||||
| 7. Round | 08/02/2022 | Newcastle United Jets | - | Melbourne City FC | 2:4 | ||||
| 14. Round | 11/02/2022 | Western Sydney Wanderers | - | Melbourne City FC | 1:3 | ||||
| 24. Round | 15/02/2022 | Melbourne City FC | - | Adelaide United | 1:2 | ||||
| 15. Round | 18/02/2022 | Melbourne City FC | - | Newcastle United Jets | 3:0 | ||||
| 8. Round | 22/02/2022 | Melbourne City FC | - | Central Coast Mariners | 3:2 | ||||
| 16. Round | 26/02/2022 | Sydney FC | - | Melbourne City FC | 1:2 | ||||
| 13. Round | 02/03/2022 | Melbourne City FC | - | Perth Glory | 2:2 | ||||
| 9. Round | 09/03/2022 | Melbourne City FC | - | Macarthur FC | 3:1 | ||||
| 18. Round | 19/03/2022 | Melbourne City FC | - | Melbourne Victory | 1:1 |  |
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| 6. Round | 23/03/2022 | Brisbane Roar | - | Melbourne City FC | 1:2 | ||||
| 23. Round | 09/04/2022 | Melbourne Victory | - | Melbourne City FC | 3:0 | |
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| 21. Round | 09/05/2022 | Melbourne City FC | - | Wellington Phoenix | 2:1 |
Australia