| 4. Round | 31/08/2021 | Newtown AFC | - | Cefn Druids | 5:0 | ||||
| 5. Round | 10/09/2021 | Caernarfon Town | - | Cefn Druids | 3:0 | ||||
| 6. Round | 18/09/2021 | Cefn Druids | - | Penybont FC | 0:3 | ||||
| 8. Round | 09/10/2021 | Bala Town | - | Cefn Druids | 1:1 | ||||
| 9. Round | 13/10/2021 | Cefn Druids | - | Aberystwyth Town | 0:1 | ||||
| 10. Round | 23/10/2021 | Haverfordwest County | - | Cefn Druids | 2:1 |  |
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| 11. Round | 29/10/2021 | Connah's Quay Nomads | - | Cefn Druids | 4:0 | ||||
| 12. Round | 05/11/2021 | Cefn Druids | - | Newtown AFC | 0:5 | ||||
| 13. Round | 09/11/2021 | Cefn Druids | - | Flint Town United | 1:1 | |
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| 14. Round | 20/11/2021 | Barry Town United | - | Cefn Druids | 1:0 | ||||
| 16. Round | 11/12/2021 | Penybont FC | - | Cefn Druids | 7:1 | ||||
| 17. Round | 17/12/2021 | Cefn Druids | - | Bala Town | 3:5 | ||||
| 20. Round | 21/01/2022 | Cefn Druids | - | Caernarfon Town | 1:3 |
Wales