| 1. Round | 09/07/2022 | Mladost Lučani | - | Spartak Subotica | 1:1 | ||||
| 2. Round | 15/07/2022 | Spartak Subotica | - | Radnik Surdulica | 2:0 | ||||
| 3. Round | 24/07/2022 | Vojvodina | - | Spartak Subotica | 0:0 | ||||
| 4. Round | 30/07/2022 | Spartak Subotica | - | FK Voždovac | 3:0 |  |
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| 5. Round | 07/08/2022 | FK Čukarički | - | Spartak Subotica | 2:0 | |
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| 6. Round | 14/08/2022 | Spartak Subotica | - | FK Javor | 2:2 | ||||
| 8. Round | 26/08/2022 | Spartak Subotica | - | TSC Bačka Topola | 0:0 | ||||
| 9. Round | 30/08/2022 | FK Novi Pazar | - | Spartak Subotica | 2:0 | ||||
| 10. Round | 03/09/2022 | Spartak Subotica | - | FK Napredak | 1:2 | |
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| 11. Round | 11/09/2022 | Mladost GAT | - | Spartak Subotica | 1:0 | ||||
| 12. Round | 19/09/2022 | Radnički Niš | - | Spartak Subotica | 3:0 | ||||
| 13. Round | 02/10/2022 | Spartak Subotica | - | FK Radnički 1923 | 1:2 | |
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| 15. Round | 15/10/2022 | Spartak Subotica | - | FK Kolubara | 2:1 | ||||
| 7. Round | 10/11/2022 | Partizan | - | Spartak Subotica | 0:1 |
Serbia