| 2. Round | 13/09/2021 | APOEL Nikosia | - | Olympiakos Nikosia | 0:1 | ||||
| 3. Round | 18/09/2021 | Olympiakos Nikosia | - | AEL Limassol | 1:1 | ||||
| 5. Round | 03/10/2021 | Olympiakos Nikosia | - | Omonia Nikosia | 1:0 |  |
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| 8. Round | 31/10/2021 | Olympiakos Nikosia | - | Apollon Limassol | 0:2 | |
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| 9. Round | 05/11/2021 | PAEEK | - | Olympiakos Nikosia | 0:0 | ||||
| 10. Round | 20/11/2021 | Olympiakos Nikosia | - | Anorthosis Famagusta | 3:2 | ||||
| 11. Round | 26/11/2021 | Ethnikos Achna | - | Olympiakos Nikosia | 1:0 | ||||
| 12. Round | 03/12/2021 | Aris Limassol | - | Olympiakos Nikosia | 1:0 | ||||
| 17. Round | 15/01/2022 | Olympiakos Nikosia | - | Paphos FC | 1:2 |  |
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| 18. Round | 23/01/2022 | Doxa Katokopias | - | Olympiakos Nikosia | 0:0 | ||||
| 19. Round | 30/01/2022 | Apollon Limassol | - | Olympiakos Nikosia | 2:1 | |
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| 15. Round | 09/02/2022 | Olympiakos Nikosia | - | AEK Larnaca | 0:0 | ||||
| 20. Round | 22/02/2022 | Olympiakos Nikosia | - | PAEEK | 1:0 |
Cyprus