| 1. Round | 22/08/2021 | Olympiakos Nikosia | - | Aris Limassol | 1:2 | ||||
| 2. Round | 13/09/2021 | APOEL Nikosia | - | Olympiakos Nikosia | 0:1 | ||||
| 10. Round | 20/11/2021 | Olympiakos Nikosia | - | Anorthosis Famagusta | 3:2 | ||||
| 13. Round | 12/12/2021 | Olympiakos Nikosia | - | APOEL Nikosia | 1:1 | ||||
| 14. Round | 19/12/2021 | AEL Limassol | - | Olympiakos Nikosia | 3:0 | ||||
| 18. Round | 23/01/2022 | Doxa Katokopias | - | Olympiakos Nikosia | 0:0 |  |
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| 21. Round | 14/02/2022 | Anorthosis Famagusta | - | Olympiakos Nikosia | 3:1 | |
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| 20. Round | 22/02/2022 | Olympiakos Nikosia | - | PAEEK | 1:0 | ||||
| 22. Round | 27/02/2022 | Olympiakos Nikosia | - | Ethnikos Achna | 0:0 |
Cyprus