| 3. Round | 04/03/2022 | Galway United | - | Waterford FC | 2:2 |  |
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| 14. Round | 02/05/2022 | Galway United | - | Longford Town | 2:0 | ||||
| 15. Round | 06/05/2022 | Cobh Ramblers | - | Galway United | 0:4 | ||||
| 16. Round | 13/05/2022 | Wexford FC | - | Galway United | 0:4 | |
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| 17. Round | 20/05/2022 | Galway United | - | Athlone Town | 3:0 | ||||
| 18. Round | 27/05/2022 | Galway United | - | Cork City | 0:1 | ||||
| 20. Round | 17/06/2022 | Bray Wanderers | - | Galway United | 1:5 | |
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| 21. Round | 24/06/2022 | Galway United | - | Treaty United | 0:0 | ||||
| 22. Round | 27/06/2022 | Longford Town | - | Galway United | 2:0 | ||||
| 29. Round | 19/08/2022 | Galway United | - | Bray Wanderers | 1:2 | ||||
| 32. Round | 16/09/2022 | Galway United | - | Cork City | 2:1 | ||||
| 33. Round | 30/09/2022 | Treaty United | - | Galway United | 1:1 | |
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| 34. Round | 07/10/2022 | Galway United | - | Athlone Town | 1:2 | |
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| 35. Round | 14/10/2022 | Wexford FC | - | Galway United | 0:0 |
Ireland