| 1. Round | 18/07/2021 | Mladost Lučani | - | FK Radnički 1923 | 0:1 |  |
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| 2. Round | 23/07/2021 | FK Radnički 1923 | - | Spartak Subotica | 3:2 | ||||
| 3. Round | 30/07/2021 | FK Napredak | - | FK Radnički 1923 | 1:0 | ||||
| 4. Round | 06/08/2021 | FK Radnički 1923 | - | Radnik Surdulica | 0:1 | |
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| 5. Round | 14/08/2021 | TSC Bačka Topola | - | FK Radnički 1923 | 4:4 | ||||
| 7. Round | 30/08/2021 | Proleter Novi Sad | - | FK Radnički 1923 | 1:1 | ||||
| 8. Round | 11/09/2021 | FK Radnički 1923 | - | Partizan | 1:3 | ||||
| 9. Round | 18/09/2021 | FK Voždovac | - | FK Radnički 1923 | 1:2 | ||||
| 10. Round | 22/09/2021 | FK Radnički 1923 | - | FK Novi Pazar | 2:1 | ||||
| 11. Round | 26/09/2021 | FK Metalac | - | FK Radnički 1923 | 4:1 | ||||
| 12. Round | 01/10/2021 | FK Radnički 1923 | - | FK Kolubara | 0:2 | ||||
| 15. Round | 31/10/2021 | FK Radnički 1923 | - | Crvena Zvezda | 0:3 | ||||
| 17. Round | 21/11/2021 | Spartak Subotica | - | FK Radnički 1923 | 1:1 | ||||
| 18. Round | 27/11/2021 | FK Radnički 1923 | - | FK Napredak | 1:2 | ||||
| 20. Round | 11/12/2021 | FK Radnički 1923 | - | TSC Bačka Topola | 0:3 | ||||
| 21. Round | 15/12/2021 | FK Čukarički | - | FK Radnički 1923 | 2:0 |
Serbia