| 2. Round | 08/08/2021 | Platense Zacatecoluca | - | Alianza | 2:2 | ||||
| 3. Round | 11/08/2021 | Luis Ángel Firpo | - | Platense Zacatecoluca | 3:2 | ||||
| 4. Round | 15/08/2021 | Platense Zacatecoluca | - | Once Municipal | 1:1 | ||||
| 6. Round | 25/08/2021 | Platense Zacatecoluca | - | Isidro Metapán | 2:1 | ||||
| 8. Round | 12/09/2021 | Platense Zacatecoluca | - | Santa Tecla FC | 1:0 | ||||
| 9. Round | 16/09/2021 | CD Águila | - | Platense Zacatecoluca | 1:0 | ||||
| 10. Round | 19/09/2021 | Platense Zacatecoluca | - | Jocoro FC | 1:1 | ||||
| 11. Round | 26/09/2021 | Municipal Limeño | - | Platense Zacatecoluca | 0:1 | ||||
| 12. Round | 02/10/2021 | Platense Zacatecoluca | - | AD Chalatenango | 2:1 | ||||
| 14. Round | 09/10/2021 | Platense Zacatecoluca | - | Luis Ángel Firpo | 1:3 | ||||
| 16. Round | 30/10/2021 | Platense Zacatecoluca | - | FAS | 0:0 | ||||
| 17. Round | 03/11/2021 | Isidro Metapán | - | Platense Zacatecoluca | 1:0 |  |
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| 18. Round | 07/11/2021 | Atlético Marte | - | Platense Zacatecoluca | 0:0 | |
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| 21. Round | 21/11/2021 | Jocoro FC | - | Platense Zacatecoluca | 1:1 | ||||
| 22. Round | 27/11/2021 | Platense Zacatecoluca | - | Municipal Limeño | 0:1 | |
El Salvador