| 2. Round | 23/01/2022 | Municipal Limeño | - | Platense Zacatecoluca | 2:1 | ||||
| 7. Round | 13/02/2022 | Alianza | - | Platense Zacatecoluca | 1:0 | ||||
| 8. Round | 20/02/2022 | Platense Zacatecoluca | - | Once Municipal | 1:0 |  |
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| 9. Round | 24/02/2022 | CD Águila | - | Platense Zacatecoluca | 2:2 | ||||
| 10. Round | 27/02/2022 | Platense Zacatecoluca | - | Jocoro FC | 2:0 | ||||
| 11. Round | 06/03/2022 | FAS | - | Platense Zacatecoluca | 2:1 | ||||
| 12. Round | 13/03/2022 | Santa Tecla FC | - | Platense Zacatecoluca | 0:1 | ||||
| 13. Round | 20/03/2022 | Platense Zacatecoluca | - | Municipal Limeño | 1:0 |  |
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| 15. Round | 03/04/2022 | Platense Zacatecoluca | - | Isidro Metapán | 2:1 | ||||
| 16. Round | 10/04/2022 | AD Chalatenango | - | Platense Zacatecoluca | 1:2 | ||||
| 17. Round | 13/04/2022 | Platense Zacatecoluca | - | Luis Ángel Firpo | 1:2 | ||||
| 18. Round | 17/04/2022 | Platense Zacatecoluca | - | Alianza | 0:1 | ||||
| 19. Round | 24/04/2022 | Once Municipal | - | Platense Zacatecoluca | 1:2 | ||||
| 20. Round | 27/04/2022 | Platense Zacatecoluca | - | CD Águila | 0:0 |
El Salvador