| 2. Round | 17/07/2022 | CD Walter Ferretti | - | H&H Export Sébaco | 1:2 | ||||
| 5. Round | 07/08/2022 | CD Walter Ferretti | - | ART Municipal Jalapa | 3:1 |  |
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| 7. Round | 14/08/2022 | Juventus Managua | - | CD Walter Ferretti | 0:1 | ||||
| 8. Round | 21/08/2022 | CD Walter Ferretti | - | Club Deportivo Ocotal | 1:3 | ||||
| 9. Round | 28/08/2022 | CD Walter Ferretti | - | Diriangén FC | 2:1 | ||||
| 10. Round | 03/09/2022 | UNAN Managua | - | CD Walter Ferretti | 0:3 | ||||
| 11. Round | 11/09/2022 | H&H Export Sébaco | - | CD Walter Ferretti | 1:1 | ||||
| 12. Round | 02/10/2022 | CD Walter Ferretti | - | Managua FC | 2:1 | ||||
| 13. Round | 24/10/2022 | CD Walter Ferretti | - | Real Estelí FC | 2:1 | ||||
| 14. Round | 27/10/2022 | ART Municipal Jalapa | - | CD Walter Ferretti | 1:0 | ||||
| 15. Round | 30/10/2022 | CD Walter Ferretti | - | Matagalpa FC | 1:0 | ||||
| 16. Round | 13/11/2022 | CD Walter Ferretti | - | Juventus Managua | 2:1 | ||||
| 17. Round | 27/11/2022 | Club Deportivo Ocotal | - | CD Walter Ferretti | 1:1 |
Nicaragua