| 1. Round | 28/07/2021 | Municipal Grecia | - | CS Cartaginés | 4:0 | ||||
| 2. Round | 01/08/2021 | Santos de Guápiles | - | Municipal Grecia | 1:0 | ||||
| 3. Round | 08/08/2021 | Municipal Grecia | - | Jicaral | 0:0 | ||||
| 6. Round | 17/08/2021 | Municipal Grecia | - | Municipal Pérez Zeledón | 1:0 | ||||
| 8. Round | 28/08/2021 | Municipal Grecia | - | Sporting FC | 1:1 | ||||
| 13. Round | 26/09/2021 | Municipal Grecia | - | Santos de Guápiles | 3:2 | ||||
| 14. Round | 02/10/2021 | Jicaral | - | Municipal Grecia | 3:1 |  |
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| 15. Round | 13/10/2021 | Municipal Grecia | - | AD Guanacasteca | 3:1 | ||||
| 16. Round | 17/10/2021 | Municipal Grecia | - | Deportivo Saprissa | 1:1 | ||||
| 17. Round | 23/10/2021 | Municipal Pérez Zeledón | - | Municipal Grecia | 3:1 | ||||
| 18. Round | 27/10/2021 | Municipal Grecia | - | LD Alajuelense | 1:2 | ||||
| 19. Round | 01/11/2021 | Sporting FC | - | Municipal Grecia | 2:1 | |
Costa Rica