| 11. Round | 31/10/2020 | Club Brugge KV | - | KV Mechelen | 2:2 | ||||
| 12. Round | 06/11/2020 | KV Mechelen | - | Sporting Charleroi | 3:3 |  |
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| 16. Round | 13/12/2020 | KV Mechelen | - | Waasland-Beveren | 2:3 | ||||
| 18. Round | 17/12/2020 | KV Mechelen | - | Club Brugge KV | 0:3 | ||||
| 25. Round | 20/01/2021 | KV Mechelen | - | Standard Liège | 0:4 | ||||
| 21. Round | 23/01/2021 | KV Mechelen | - | KAS Eupen | 3:0 | ||||
| 22. Round | 26/01/2021 | Waasland-Beveren | - | KV Mechelen | 2:3 | ||||
| 23. Round | 30/01/2021 | KV Mechelen | - | KRC Genk | 0:0 | ||||
| 27. Round | 19/02/2021 | KV Mechelen | - | KAA Gent | 1:1 | ||||
| 28. Round | 27/02/2021 | KV Oostende | - | KV Mechelen | 2:0 | ||||
| 29. Round | 07/03/2021 | RSC Anderlecht | - | KV Mechelen | 1:1 | ||||
| 31. Round | 21/03/2021 | KV Mechelen | - | Oud-Heverlee Leuven | 2:2 | |
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| 32. Round | 03/04/2021 | Sint-Truidense VV | - | KV Mechelen | 2:1 | ||||
| 33. Round | 10/04/2021 | KV Mechelen | - | SV Zulte Waregem | 4:2 | ||||
| 34. Round | 18/04/2021 | KV Kortrijk | - | KV Mechelen | 1:4 | |
Belgium
