| 7. Round | 06/09/2021 | Atlético FC | - | Valledupar FC | 3:2 | ||||
| 8. Round | 11/09/2021 | Valledupar FC | - | Orsomarso SC | 1:2 | ||||
| 10. Round | 28/09/2021 | Boyacá Chicó | - | Valledupar FC | 2:0 | ||||
| 11. Round | 03/10/2021 | Valledupar FC | - | Fortaleza FC | 1:1 |  |
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| 12. Round | 09/10/2021 | Real Santander | - | Valledupar FC | 1:1 | ||||
| 13. Round | 19/10/2021 | Valledupar FC | - | Cortuluá | 1:2 | ||||
| 14. Round | 24/10/2021 | Unión Magdalena | - | Valledupar FC | 3:1 | ||||
| 15. Round | 30/10/2021 | Valledupar FC | - | Boca Juniors de Cali | 2:1 |
Colombia