| 1. Round | 13/07/2022 | Boyacá Chicó | - | Barranquilla FC | 1:0 | ||||
| 4. Round | 30/07/2022 | Llaneros FC | - | Barranquilla FC | 1:1 | ||||
| 5. Round | 03/08/2022 | Barranquilla FC | - | Boca Juniors de Cali | 1:1 | ||||
| 6. Round | 09/08/2022 | Barranquilla FC | - | Leones FC | 3:1 |  |
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| 7. Round | 13/08/2022 | Bogotá FC | - | Barranquilla FC | 1:0 | ||||
| 8. Round | 20/08/2022 | Barranquilla FC | - | Deportes Quindío | 1:1 | |
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| 15. Round | 01/10/2022 | Valledupar FC | - | Barranquilla FC | 0:1 | ||||
| 16. Round | 08/10/2022 | Barranquilla FC | - | Orsomarso SC | 2:0 | |
Colombia