| 1. Round | 06/08/2005 | Sporting Lokeren | - | KRC Genk | 1:1 | ||||
| 4. Round | 28/08/2005 | KSV Roeselare | - | Sporting Lokeren | 4:0 | ||||
| 6. Round | 17/09/2005 | Sint-Truidense VV | - | Sporting Lokeren | 1:2 |  |
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| 7. Round | 21/09/2005 | Sporting Lokeren | - | KSK Beveren | 1:2 | |
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| 8. Round | 24/09/2005 | Club Brugge KV | - | Sporting Lokeren | 0:1 | ||||
| 10. Round | 15/10/2005 | Sporting Lokeren | - | Sporting Charleroi | 4:2 | ||||
| 11. Round | 22/10/2005 | KVC Westerlo | - | Sporting Lokeren | 1:1 | ||||
| 12. Round | 28/10/2005 | Sporting Lokeren | - | RSC Anderlecht | 2:2 | ||||
| 5. Round | 09/11/2005 | Sporting Lokeren | - | Lierse SK (old) | 1:0 | ||||
| 14. Round | 19/11/2005 | Sporting Lokeren | - | SV Zulte Waregem | 2:3 | ||||
| 16. Round | 03/12/2005 | Sporting Lokeren | - | Cercle Brugge | 2:1 | ||||
| 17. Round | 09/12/2005 | Germinal Beerschot | - | Sporting Lokeren | 2:1 | ||||
| 15. Round | 14/12/2005 | RAA La Louviére | - | Sporting Lokeren | 1:1 | |
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| 19. Round | 21/01/2006 | Sporting Lokeren | - | Excelsior Mouscron | 1:1 | |
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| 23. Round | 18/02/2006 | Sporting Lokeren | - | Sint-Truidense VV | 1:2 | ||||
| 28. Round | 25/03/2006 | Sporting Lokeren | - | KVC Westerlo | 3:2 |
Croatia