| 5. Round | 06/11/2021 | CA Bizertin | - | ES Métlaoui | 1:0 | ||||
| 6. Round | 17/11/2021 | CS Sfaxien | - | CA Bizertin | 1:2 | ||||
| 7. Round | 21/11/2021 | CA Bizertin | - | US Ben Guerdane | 1:2 |  |
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| 8. Round | 19/02/2022 | CA Bizertin | - | US Tataouine | 0:1 | ||||
| 9. Round | 26/02/2022 | ES Hammam Sousse | - | CA Bizertin | 1:0 | ||||
| 10. Round | 09/03/2022 | Espérance de Tunis | - | CA Bizertin | 4:0 | ||||
| 11. Round | 13/03/2022 | CA Bizertin | - | CS Hammam-Lif | 2:0 | ||||
| 12. Round | 06/04/2022 | ES Métlaoui | - | CA Bizertin | 2:1 | ||||
| 13. Round | 10/04/2022 | CA Bizertin | - | CS Sfaxien | 2:0 | ||||
| 14. Round | 18/04/2022 | US Ben Guerdane | - | CA Bizertin | 0:1 |
Tunisia