| Group B | 16/09/2021 | FC Flora | - | KAA Gent | 0:1 | ||||
| Group B | 30/09/2021 | KAA Gent | - | Anorthosis Famagusta | 2:0 | ||||
| Group B | 04/11/2021 | KAA Gent | - | Partizan | 1:1 |  |
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| Group B | 25/11/2021 | Anorthosis Famagusta | - | KAA Gent | 1:0 | ||||
| Group B | 09/12/2021 | KAA Gent | - | FC Flora | 1:0 | ||||
| Round of 16 | 10/03/2022 | PAOK Saloniki | - | KAA Gent | 1:0 | ||||
| Round of 16 | 17/03/2022 | KAA Gent | - | PAOK Saloniki | 1:2 |
Netherlands