1. Round | 08/08/2021 | Vida | - | Lobos UPNFM | 1:1 | ||||
2. Round | 11/08/2021 | Marathón | - | Lobos UPNFM | 5:1 | ||||
3. Round | 15/08/2021 | Lobos UPNFM | - | Honduras Progreso | 3:0 | ||||
4. Round | 22/08/2021 | Lobos UPNFM | - | Platense | 3:0 | ||||
5. Round | 26/08/2021 | Real España | - | Lobos UPNFM | 5:3 | ||||
6. Round | 31/08/2021 | Motagua | - | Lobos UPNFM | 0:0 | ||||
8. Round | 12/09/2021 | Lobos UPNFM | - | Olimpia | 0:0 | ||||
16. Round | 27/10/2021 | Real Sociedad | - | Lobos UPNFM | 0:3 |