| 1. Round | 13/08/2021 | Gudja United | - | Sirens FC | 0:1 | ||||
| 2. Round | 22/08/2021 | Hibernians FC | - | Gudja United | 2:1 | ||||
| 4. Round | 19/09/2021 | Sliema Wanderers | - | Gudja United | 2:3 | ||||
| 5. Round | 25/09/2021 | Gudja United | - | Valletta FC | 2:0 | ||||
| 6. Round | 16/10/2021 | Birkirkara FC | - | Gudja United | 2:0 |  |
|||
| 7. Round | 23/10/2021 | Gudja United | - | Hamrun Spartans | 1:3 | ||||
| 9. Round | 20/11/2021 | Gudja United | - | Floriana FC | 0:1 | ||||
| 10. Round | 28/11/2021 | Gżira United | - | Gudja United | 3:2 |  |
|
||
| 11. Round | 04/12/2021 | Mosta FC | - | Gudja United | 0:3 | |
|||
| 12. Round | 13/12/2021 | Sirens FC | - | Gudja United | 0:0 |  |
|||
| 14. Round | 19/01/2022 | St. Luċija FC | - | Gudja United | 0:3 | |
|||
| 15. Round | 22/01/2022 | Gudja United | - | Sliema Wanderers | 1:0 | |
|||
| 16. Round | 30/01/2022 | Valletta FC | - | Gudja United | 1:3 | ||||
| 17. Round | 06/02/2022 | Gudja United | - | Birkirkara FC | 0:1 |
Malta