| 1. Round | 08/08/2020 | FK Senica | - | MŠK Žilina | 0:4 | ||||
| 2. Round | 12/08/2020 | ŠKF Sereď | - | FK Senica | 4:0 |  |
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| 3. Round | 15/08/2020 | FK Senica | - | MFK Zemplín Michalovce | 3:0 | ||||
| 5. Round | 29/08/2020 | FK Senica | - | FC Nitra | 0:0 | ||||
| 6. Round | 11/09/2020 | Zlaté Moravce | - | FK Senica | 2:2 | ||||
| 8. Round | 26/09/2020 | FK Senica | - | Spartak Trnava | 0:2 | ||||
| 4. Round | 30/09/2020 | Slovan Bratislava | - | FK Senica | 2:0 | ||||
| 9. Round | 04/10/2020 | AS Trenčín | - | FK Senica | 0:1 |  |
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| 10. Round | 17/10/2020 | FK Senica | - | MFK Ružomberok | 1:2 | ||||
| 11. Round | 24/10/2020 | FK Pohronie | - | FK Senica | 1:2 | ||||
| 12. Round | 31/10/2020 | MŠK Žilina | - | FK Senica | 3:1 | ||||
| 13. Round | 17/11/2020 | FK Senica | - | ŠKF Sereď | 2:2 | ||||
| 14. Round | 21/11/2020 | MFK Zemplín Michalovce | - | FK Senica | 0:1 | ||||
| 15. Round | 29/11/2020 | FK Senica | - | Slovan Bratislava | 0:3 | ||||
| 16. Round | 05/12/2020 | FC Nitra | - | FK Senica | 1:1 | ||||
| 17. Round | 12/12/2020 | FK Senica | - | Zlaté Moravce | 1:1 | ||||
| 18. Round | 15/12/2020 | FC DAC 1904 | - | FK Senica | 2:0 | |
Nigeria