| 2. Round | 25/08/2021 | Kaizer Chiefs | - | Baroka FC | 2:1 | ||||
| 3. Round | 12/09/2021 | Mamelodi Sundowns | - | Kaizer Chiefs | 2:0 | ||||
| 6. Round | 02/10/2021 | AmaZulu FC | - | Kaizer Chiefs | 1:1 | ||||
| 7. Round | 16/10/2021 | Kaizer Chiefs | - | Chippa United | 4:0 | ||||
| 8. Round | 24/10/2021 | SuperSport United | - | Kaizer Chiefs | 1:2 | ||||
| 12. Round | 28/11/2021 | Moroka Swallows | - | Kaizer Chiefs | 1:3 | ||||
| 15. Round | 12/12/2021 | Kaizer Chiefs | - | Sekhukhune United | 2:0 | ||||
| 16. Round | 19/12/2021 | Royal AM | - | Kaizer Chiefs | 1:0 | ||||
| 18. Round | 15/02/2022 | Cape Town City FC | - | Kaizer Chiefs | 0:0 | ||||
| 20. Round | 26/02/2022 | Baroka FC | - | Kaizer Chiefs | 0:1 | ||||
| 21. Round | 05/03/2022 | Orlando Pirates | - | Kaizer Chiefs | 1:2 | ||||
| 22. Round | 19/03/2022 | Kaizer Chiefs | - | Golden Arrows | 0:1 | ||||
| 23. Round | 02/04/2022 | Chippa United | - | Kaizer Chiefs | 1:3 | ||||
| 24. Round | 05/04/2022 | Kaizer Chiefs | - | TS Galaxy | 0:0 | ||||
| 29. Round | 14/05/2022 | Sekhukhune United | - | Kaizer Chiefs | 0:1 | ||||
| 30. Round | 21/05/2022 | Kaizer Chiefs | - | Moroka Swallows | 2:2 |
South Africa