| 1. Round | 06/02/2022 | Club Aurora | - | CD Guabirá | 0:0 | ||||
| 2. Round | 12/02/2022 | Oriente Petrolero | - | Club Aurora | 2:0 | ||||
| 3. Round | 19/02/2022 | Club Aurora | - | Atlético Palmaflor | 1:2 | ||||
| 4. Round | 27/02/2022 | Universitario de Sucre | - | Club Aurora | 1:1 |  |
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| 5. Round | 06/03/2022 | Real Santa Cruz | - | Club Aurora | 2:2 | ||||
| 6. Round | 13/03/2022 | Club Aurora | - | Jorge Wilstermann | 1:0 | ||||
| 7. Round | 01/04/2022 | Nacional Potosí | - | Club Aurora | 2:1 | ||||
| 8. Round | 11/04/2022 | Club Aurora | - | The Strongest | 1:0 | ||||
| 9. Round | 17/04/2022 | CD Guabirá | - | Club Aurora | 3:2 | ||||
| 10. Round | 20/04/2022 | Club Aurora | - | Oriente Petrolero | 1:1 | ||||
| 12. Round | 30/04/2022 | Club Aurora | - | Universitario de Sucre | 3:0 | |
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| 14. Round | 12/05/2022 | Club Aurora | - | Real Santa Cruz | 2:4 | ||||
| 15. Round | 15/05/2022 | Club Aurora | - | Nacional Potosí | 2:3 | ||||
| 16. Round | 21/05/2022 | The Strongest | - | Club Aurora | 1:0 |
Lesotho