| 1. Round | 22/08/2021 | Moroka Swallows | - | Royal AM | 1:0 | ||||
| 2. Round | 25/08/2021 | AmaZulu FC | - | Moroka Swallows | 0:0 | ||||
| 4. Round | 19/09/2021 | Moroka Swallows | - | SuperSport United | 0:3 | ||||
| 5. Round | 24/09/2021 | Moroka Swallows | - | Cape Town City FC | 0:0 | ||||
| 6. Round | 03/10/2021 | Mamelodi Sundowns | - | Moroka Swallows | 3:0 | ||||
| 7. Round | 17/10/2021 | Moroka Swallows | - | Stellenbosch FC | 1:1 | ||||
| 8. Round | 24/10/2021 | Chippa United | - | Moroka Swallows | 0:0 | ||||
| 9. Round | 02/11/2021 | Golden Arrows | - | Moroka Swallows | 0:0 | ||||
| 10. Round | 07/11/2021 | Moroka Swallows | - | Sekhukhune United | 0:1 | ||||
| 12. Round | 28/11/2021 | Moroka Swallows | - | Kaizer Chiefs | 1:3 | ||||
| 13. Round | 04/12/2021 | Moroka Swallows | - | Maritzburg United | 1:1 | ||||
| 14. Round | 08/12/2021 | Baroka FC | - | Moroka Swallows | 0:1 | ||||
| 15. Round | 11/12/2021 | Moroka Swallows | - | Marumo Gallants | 0:1 | ||||
| 22. Round | 14/12/2021 | Moroka Swallows | - | Orlando Pirates | 1:1 | ||||
| 16. Round | 18/12/2021 | Cape Town City FC | - | Moroka Swallows | 2:1 | ||||
| 17. Round | 22/12/2021 | Moroka Swallows | - | Golden Arrows | 2:2 |
South Africa