| 14. Round | 08/12/2021 | AmaZulu FC | - | Orlando Pirates | 1:1 | ||||
| 15. Round | 11/12/2021 | Orlando Pirates | - | TS Galaxy | 2:0 | ||||
| 22. Round | 14/12/2021 | Moroka Swallows | - | Orlando Pirates | 1:1 | ||||
| 16. Round | 17/12/2021 | Mamelodi Sundowns | - | Orlando Pirates | 4:1 | ||||
| 17. Round | 20/12/2021 | Orlando Pirates | - | Marumo Gallants | 2:1 | ||||
| 23. Round | 23/12/2021 | Orlando Pirates | - | AmaZulu FC | 2:1 | ||||
| 18. Round | 16/02/2022 | Orlando Pirates | - | Golden Arrows | 0:0 | ||||
| 21. Round | 05/03/2022 | Orlando Pirates | - | Kaizer Chiefs | 1:2 | ||||
| 24. Round | 06/04/2022 | Sekhukhune United | - | Orlando Pirates | 0:1 | ||||
| 25. Round | 12/04/2022 | Baroka FC | - | Orlando Pirates | 0:0 | ||||
| 26. Round | 27/04/2022 | Orlando Pirates | - | Chippa United | 0:0 | ||||
| 27. Round | 02/05/2022 | TS Galaxy | - | Orlando Pirates | 1:0 | ||||
| 29. Round | 24/05/2022 | Orlando Pirates | - | Maritzburg United | 4:1 |  |
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| 28. Round | 27/05/2022 | Royal AM | - | Orlando Pirates | 2:2 | ||||
| 30. Round | 30/05/2022 | SuperSport United | - | Orlando Pirates | 2:0 |
South Africa