1. Round | 24/07/2021 | KV Kortrijk | - | RFC Seraing | 2:0 | ||||
2. Round | 31/07/2021 | RFC Seraing | - | KV Mechelen | 1:0 | ||||
3. Round | 08/08/2021 | RSC Anderlecht | - | RFC Seraing | 3:0 | ||||
4. Round | 14/08/2021 | RFC Seraing | - | KV Oostende | 2:3 | ||||
5. Round | 21/08/2021 | RFC Seraing | - | Cercle Brugge | 2:1 | ||||
6. Round | 28/08/2021 | KAS Eupen | - | RFC Seraing | 1:2 | ||||
8. Round | 19/09/2021 | Royal Antwerp FC | - | RFC Seraing | 2:1 | ||||
10. Round | 03/10/2021 | RFC Seraing | - | SV Zulte Waregem | 5:1 | ||||
11. Round | 16/10/2021 | Union Saint-Gilloise | - | RFC Seraing | 4:2 | ||||
13. Round | 30/10/2021 | K Beerschot VA | - | RFC Seraing | 3:0 | ||||
14. Round | 07/11/2021 | RFC Seraing | - | KAA Gent | 0:0 | ||||
15. Round | 20/11/2021 | Oud-Heverlee Leuven | - | RFC Seraing | 1:3 | ||||
16. Round | 27/11/2021 | RFC Seraing | - | Sint-Truidense VV | 2:0 | ||||
18. Round | 11/12/2021 | RFC Seraing | - | RSC Anderlecht | 0:5 | ||||
19. Round | 14/12/2021 | Cercle Brugge | - | RFC Seraing | 2:0 | ||||
22. Round | 18/01/2022 | RFC Seraing | - | Union Saint-Gilloise | 0:4 |