| 1. Round | 01/08/2009 | KV Kortrijk | - | RSC Anderlecht | 0:2 | ||||
| 2. Round | 08/08/2009 | RSC Anderlecht | - | Cercle Brugge | 3:2 | ||||
| 3. Round | 15/08/2009 | RSC Anderlecht | - | KVC Westerlo | 3:0 | ||||
| 4. Round | 22/08/2009 | SV Zulte Waregem | - | RSC Anderlecht | 0:2 |  |
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| 5. Round | 30/08/2009 | RSC Anderlecht | - | Standard Liège | 1:1 | ||||
| 6. Round | 12/09/2009 | Sint-Truidense VV | - | RSC Anderlecht | 2:1 | |
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| 8. Round | 24/09/2009 | Excelsior Mouscron | - | RSC Anderlecht | annull. | ||||
| 9. Round | 27/09/2009 | RSC Anderlecht | - | Germinal Beerschot | 1:0 | ||||
| 10. Round | 04/10/2009 | Club Brugge KV | - | RSC Anderlecht | 4:2 | ||||
| 11. Round | 17/10/2009 | RSC Anderlecht | - | Sporting Charleroi | 2:0 | ||||
| 12. Round | 25/10/2009 | KV Mechelen | - | RSC Anderlecht | 0:2 | ||||
| 13. Round | 31/10/2009 | RSC Anderlecht | - | Sporting Lokeren | 2:0 | ||||
| 16. Round | 27/11/2009 | RSC Anderlecht | - | KV Kortrijk | 1:0 | ||||
| 18. Round | 11/12/2009 | KVC Westerlo | - | RSC Anderlecht | 0:2 | ||||
| 21. Round | 30/12/2009 | RSC Anderlecht | - | SV Zulte Waregem | 2:1 | ||||
| 27. Round | 21/02/2010 | RSC Anderlecht | - | KV Mechelen | 2:0 | ||||
| 30. Round | 21/03/2010 | Sporting Lokeren | - | RSC Anderlecht | 0:4 |
Belgium