| 6. Round | 19/09/1999 | KVC Westerlo | - | Lierse SK (old) | 0:2 | ||||
| 7. Round | 25/09/1999 | Lierse SK (old) | - | KAA Gent | 2:1 | ||||
| 11. Round | 30/10/1999 | Lierse SK (old) | - | Excelsior Mouscron | 1:0 | ||||
| 14. Round | 20/11/1999 | Lierse SK (old) | - | Lommelse SK | 4:0 | ||||
| 15. Round | 26/11/1999 | Club Brugge KV | - | Lierse SK (old) | 1:0 | ||||
| 16. Round | 04/12/1999 | Lierse SK (old) | - | Sint-Truidense VV | 0:0 | ||||
| 17. Round | 11/12/1999 | Sporting Lokeren | - | Lierse SK (old) | 5:1 |  |
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| 20. Round | 23/01/2000 | RSC Anderlecht | - | Lierse SK (old) | 2:0 | ||||
| 21. Round | 30/01/2000 | Lierse SK (old) | - | KRC Harelbeke | 2:0 | ||||
| 23. Round | 12/02/2000 | Lierse SK (old) | - | KVC Westerlo | 7:0 | ||||
| 28. Round | 25/03/2000 | Excelsior Mouscron | - | Lierse SK (old) | 3:3 | ||||
| 29. Round | 01/04/2000 | Lierse SK (old) | - | KSK Beveren | 1:3 | ||||
| 30. Round | 07/04/2000 | Lierse SK (old) | - | Verbroedering Geel | 2:2 |  |
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| 31. Round | 15/04/2000 | Lommelse SK | - | Lierse SK (old) | 1:0 | ||||
| 32. Round | 21/04/2000 | Lierse SK (old) | - | Club Brugge KV | 1:0 | |
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