| 1. Round | 12/08/2021 | Balzan FC | - | Sliema Wanderers | 1:0 | ||||
| 2. Round | 20/08/2021 | Sliema Wanderers | - | Floriana FC | 0:0 | ||||
| 3. Round | 11/09/2021 | Gżira United | - | Sliema Wanderers | 1:1 | ||||
| 4. Round | 19/09/2021 | Sliema Wanderers | - | Gudja United | 2:3 | ||||
| 6. Round | 17/10/2021 | Sliema Wanderers | - | Hibernians FC | 0:3 | ||||
| 7. Round | 24/10/2021 | St. Luċija FC | - | Sliema Wanderers | 0:0 |  |
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| 8. Round | 31/10/2021 | Sliema Wanderers | - | Mosta FC | 2:3 | ||||
| 13. Round | 19/12/2021 | Floriana FC | - | Sliema Wanderers | 2:0 | ||||
| 14. Round | 18/01/2022 | Sliema Wanderers | - | Gżira United | 1:3 | ||||
| 15. Round | 22/01/2022 | Gudja United | - | Sliema Wanderers | 1:0 | |
Malta