| 27. Round | 27/02/2021 | Irtysh Omsk | - | FK Neftekhimik | 1:2 |  |
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| 28. Round | 06/03/2021 | Alania Vladikavkaz | - | Irtysh Omsk | 1:0 | |
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| 30. Round | 14/03/2021 | Krylia Sovetov | - | Irtysh Omsk | 3:1 | ||||
| 32. Round | 24/03/2021 | Fakel Voronezh | - | Irtysh Omsk | 3:1 | ||||
| 33. Round | 28/03/2021 | Irtysh Omsk | - | Shinnik Yaroslavl | 0:0 | ||||
| 34. Round | 03/04/2021 | Torpedo Moskva | - | Irtysh Omsk | 1:0 | ||||
| 36. Round | 11/04/2021 | FK Krasnodar 2 | - | Irtysh Omsk | 2:0 | ||||
| 37. Round | 17/04/2021 | Irtysh Omsk | - | Baltika Kaliningrad | 0:1 | |
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| 38. Round | 24/04/2021 | Veles Moskva | - | Irtysh Omsk | 2:1 | |
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| 42. Round | 15/05/2021 | Enisey Krasnoyarsk | - | Irtysh Omsk | 2:1 |
Russia