| 1. Round | 20/07/2021 | Zvezda Perm | - | FK Novosibirsk | 1:1 | ||||
| 2. Round | 24/07/2021 | FK Tyumen | - | FK Novosibirsk | 0:3 | ||||
| 3. Round | 01/08/2021 | FK Novosibirsk | - | FK Ural 2 | 1:3 | ||||
| 6. Round | 21/08/2021 | Torpedo Miass | - | FK Novosibirsk | 1:1 | ||||
| 7. Round | 29/08/2021 | FK Novosibirsk | - | Lada Tolyatti | 2:0 | ||||
| 9. Round | 12/09/2021 | Zenit Izhevsk | - | FK Novosibirsk | 0:1 | ||||
| 10. Round | 16/09/2021 | FK Amkar Perm | - | FK Novosibirsk | 1:0 | ||||
| 13. Round | 13/10/2021 | Irtysh Omsk | - | FK Novosibirsk | 3:1 | ||||
| 16. Round | 20/10/2021 | FK Novosibirsk | - | Irtysh Omsk | 2:0 |
Russia