| 1. Round | 28/08/2021 | Persipura Jayapura | - | Persita Tangerang | 1:2 |  |
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| 2. Round | 10/09/2021 | Persela Lamongan | - | Persipura Jayapura | 1:0 | ||||
| 3. Round | 19/09/2021 | Persipura Jayapura | - | Persija Jakarta | 0:0 | ||||
| 4. Round | 24/09/2021 | Persiraja Banda Aceh | - | Persipura Jayapura | 1:2 | ||||
| 5. Round | 29/09/2021 | Persipura Jayapura | - | Arema Cronus FC | 0:1 | ||||
| 6. Round | 03/10/2021 | Madura United | - | Persipura Jayapura | 2:2 | ||||
| 7. Round | 16/10/2021 | Persipura Jayapura | - | Persebaya Surabaya | 1:3 | ||||
| 8. Round | 21/10/2021 | Persik Kediri | - | Persipura Jayapura | 4:2 |  |
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| 9. Round | 25/10/2021 | Persipura Jayapura | - | PS Barito Putera | 0:1 | ||||
| 10. Round | 30/10/2021 | Persib Bandung | - | Persipura Jayapura | 3:0 | ||||
| 11. Round | 05/11/2021 | Persipura Jayapura | - | Bali United | 0:1 |  |
Indonesia