| 1. Round | 31/07/2010 | RSC Anderlecht | - | KAS Eupen | 4:1 | ||||
| 3. Round | 14/08/2010 | RSC Anderlecht | - | Germinal Beerschot | 4:0 |  |
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| 17. Round | 27/11/2010 | RSC Anderlecht | - | Sporting Charleroi | 4:1 | |
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| 18. Round | 05/12/2010 | SV Zulte Waregem | - | RSC Anderlecht | 1:2 |  |
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| 19. Round | 12/12/2010 | RSC Anderlecht | - | Sporting Lokeren | 0:0 | ||||
| 20. Round | 19/12/2010 | Club Brugge KV | - | RSC Anderlecht | 0:2 | ||||
| 21. Round | 26/12/2010 | RSC Anderlecht | - | Lierse SK (old) | 6:0 | ||||
| 23. Round | 23/01/2011 | RSC Anderlecht | - | Standard Liège | 2:0 | ||||
| 24. Round | 30/01/2011 | KV Mechelen | - | RSC Anderlecht | 0:0 | ||||
| 25. Round | 05/02/2011 | RSC Anderlecht | - | Sint-Truidense VV | 2:0 | ||||
| 26. Round | 12/02/2011 | RSC Anderlecht | - | Cercle Brugge | 1:0 | ||||
| 27. Round | 20/02/2011 | KVC Westerlo | - | RSC Anderlecht | 2:0 | ||||
| 28. Round | 04/03/2011 | RSC Anderlecht | - | KRC Genk | 1:1 | ||||
| 29. Round | 12/03/2011 | KAS Eupen | - | RSC Anderlecht | 1:1 | ||||
| 30. Round | 20/03/2011 | RSC Anderlecht | - | KAA Gent | 3:2 | |
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Belgium