| 2. Round | 21/08/2017 | Wolverhampton Wanderers U23 | - | Southampton FC U23 | 3:0 | ||||
| 3. Round | 25/08/2017 | Southampton FC U23 | - | Blackburn Rovers U23 | 0:1 | ||||
| 4. Round | 11/09/2017 | Aston Villa U23 | - | Southampton FC U23 | 4:0 | ||||
| 5. Round | 18/09/2017 | Southampton FC U23 | - | Stoke City U23 | 3:0 | ||||
| 6. Round | 25/09/2017 | West Bromwich Albion U23 | - | Southampton FC U23 | 0:1 | ||||
| 8. Round | 20/10/2017 | Norwich City U23 | - | Southampton FC U23 | 3:0 | ||||
| 11. Round | 26/11/2017 | Middlesbrough FC U23 | - | Southampton FC U23 | 3:3 | ||||
| 12. Round | 11/12/2017 | Southampton FC U23 | - | Wolverhampton Wanderers U23 | 2:4 | ||||
| 15. Round | 15/01/2018 | Southampton FC U23 | - | Aston Villa U23 | 1:4 | ||||
| 18. Round | 19/02/2018 | Newcastle United U23 | - | Southampton FC U23 | 1:5 |  |
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| 20. Round | 12/03/2018 | Southampton FC U23 | - | Norwich City U23 | 2:1 | |
Ireland