| 4. Round | 07/08/2022 | Spartak Trnava | - | MŠK Žilina | 2:2 | ||||
| 5. Round | 13/08/2022 | MŠK Žilina | - | Zlaté Moravce | 1:0 | ||||
| 6. Round | 21/08/2022 | Slovan Bratislava | - | MŠK Žilina | 3:1 | ||||
| 7. Round | 26/08/2022 | MŠK Žilina | - | MFK Zemplín Michalovce | 2:0 | ||||
| 8. Round | 30/08/2022 | MFK Skalica | - | MŠK Žilina | 1:0 | ||||
| 9. Round | 02/09/2022 | MŠK Žilina | - | FK Železiarne Podbrezová | 0:1 |  |
|||
| 11. Round | 17/09/2022 | MŠK Žilina | - | Tatran Liptovský Mikuláš | 4:2 | ||||
| 12. Round | 01/10/2022 | MŠK Žilina | - | AS Trenčín | 1:1 | ||||
| 13. Round | 09/10/2022 | FC DAC 1904 | - | MŠK Žilina | 5:2 | ||||
| 14. Round | 15/10/2022 | Dukla Banská Bystrica | - | MŠK Žilina | 2:1 | ||||
| 15. Round | 22/10/2022 | MŠK Žilina | - | Spartak Trnava | 1:2 | ||||
| 17. Round | 06/11/2022 | MŠK Žilina | - | Slovan Bratislava | 4:1 |  |
|||
| 18. Round | 12/11/2022 | MFK Zemplín Michalovce | - | MŠK Žilina | 3:2 | |
|||
| 20. Round | 19/02/2023 | FK Železiarne Podbrezová | - | MŠK Žilina | 3:1 | ||||
| 21. Round | 26/02/2023 | MŠK Žilina | - | MFK Ružomberok | 2:0 | ||||
| 22. Round | 04/03/2023 | Tatran Liptovský Mikuláš | - | MŠK Žilina | 1:2 |
Slovakia