| 2. Round | 08/08/2021 | Zagłębie Sosnowiec | - | Widzew Łódź | 1:2 | ||||
| 3. Round | 15/08/2021 | Widzew Łódź | - | Chrobry Głogów | 2:0 | ||||
| 4. Round | 18/08/2021 | Arka Gdynia | - | Widzew Łódź | 3:1 |  |
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| 5. Round | 21/08/2021 | Widzew Łódź | - | OKS Stomil Olsztyn | 2:0 | ||||
| 6. Round | 28/08/2021 | Widzew Łódź | - | KS Polkowice | 4:2 | ||||
| 7. Round | 05/09/2021 | Odra Opole | - | Widzew Łódź | 0:0 | ||||
| 9. Round | 19/09/2021 | GKS Tychy '71 | - | Widzew Łódź | 1:1 | ||||
| 11. Round | 02/10/2021 | Puszcza Niepołomice | - | Widzew Łódź | 0:1 | ||||
| 13. Round | 15/10/2021 | Korona Kielce | - | Widzew Łódź | 0:1 | |
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| 14. Round | 24/10/2021 | Widzew Łódź | - | ŁKS Łódź | 2:2 |  |
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| 15. Round | 30/10/2021 | Resovia Rzeszów | - | Widzew Łódź | 1:0 | ||||
| 16. Round | 07/11/2021 | Widzew Łódź | - | Miedź Legnica | 1:1 | ||||
| 17. Round | 13/11/2021 | Podbeskidzie Bielsko-Biała | - | Widzew Łódź | 4:0 | ||||
| 18. Round | 22/11/2021 | Sandecja Nowy Sącz | - | Widzew Łódź | 2:2 | ||||
| 19. Round | 28/11/2021 | Widzew Łódź | - | Zagłębie Sosnowiec | 3:2 | ||||
| 29. Round | 23/04/2022 | GKS Jastrzębie | - | Widzew Łódź | 0:2 |
Poland