| 1. Round | 12/08/2000 | Werder Bremen | - | Energie Cottbus | 3:1 | ||||
| 2. Round | 18/08/2000 | Energie Cottbus | - | Borussia Dortmund | 1:4 | ||||
| 5. Round | 16/09/2000 | SC Freiburg | - | Energie Cottbus | 4:1 | ||||
| 7. Round | 30/09/2000 | 1. FC Kaiserslautern | - | Energie Cottbus | 1:1 |  |
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| 8. Round | 14/10/2000 | Energie Cottbus | - | Bayern München | 1:0 | ||||
| 9. Round | 21/10/2000 | Hertha BSC | - | Energie Cottbus | 3:1 |  |
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| 10. Round | 27/10/2000 | Energie Cottbus | - | VfL Bochum | 2:0 | |
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| 12. Round | 12/11/2000 | Energie Cottbus | - | VfB Stuttgart | 2:1 | ||||
| 13. Round | 19/11/2000 | SpVgg Unterhaching | - | Energie Cottbus | 2:1 | ||||
| 14. Round | 25/11/2000 | Energie Cottbus | - | 1. FC Köln | 0:2 | ||||
| 16. Round | 10/12/2000 | Hamburger SV | - | Energie Cottbus | 2:1 | ||||
| 17. Round | 13/12/2000 | Energie Cottbus | - | TSV 1860 München | 2:3 | ||||
| 21. Round | 09/02/2001 | Eintracht Frankfurt | - | Energie Cottbus | 1:0 | ||||
| 23. Round | 23/02/2001 | Bayer Leverkusen | - | Energie Cottbus | 1:3 | ||||
| 24. Round | 03/03/2001 | Energie Cottbus | - | 1. FC Kaiserslautern | 0:2 | ||||
| 27. Round | 01/04/2001 | VfL Bochum | - | Energie Cottbus | 1:0 |
North Macedonia