| 1. Round | 14/08/2021 | Fatih Karagümrük | - | Gaziantep FK | 3:2 | ||||
| 2. Round | 21/08/2021 | Gaziantep FK | - | Beşiktaş | 0:0 | ||||
| 3. Round | 28/08/2021 | Yeni Malatyaspor | - | Gaziantep FK | 2:0 | ||||
| 4. Round | 13/09/2021 | Gaziantep FK | - | Antalyaspor | 2:0 | ||||
| 6. Round | 22/09/2021 | Gaziantep FK | - | İstanbul Başakşehir | 1:0 | ||||
| 9. Round | 18/10/2021 | Hatayspor | - | Gaziantep FK | 2:1 | ||||
| 20. Round | 08/01/2022 | Gaziantep FK | - | Fatih Karagümrük | 3:1 | ||||
| 21. Round | 14/01/2022 | Beşiktaş | - | Gaziantep FK | 1:0 | ||||
| 23. Round | 23/01/2022 | Antalyaspor | - | Gaziantep FK | 0:0 | ||||
| 25. Round | 12/02/2022 | İstanbul Başakşehir | - | Gaziantep FK | 2:0 | ||||
| 26. Round | 20/02/2022 | Gaziantep FK | - | Adana Demirspor | 0:3 | ||||
| 27. Round | 27/02/2022 | Altay Izmir | - | Gaziantep FK | 3:2 | ||||
| 37. Round | 15/05/2022 | Alanyaspor | - | Gaziantep FK | 3:0 | ||||
| 38. Round | 20/05/2022 | Gaziantep FK | - | Çaykur Rizespor | 2:0 |  |
Norway