| 1. Round | 29/08/2021 | UD SS Reyes | - | Extremadura UD | 1:0 |  |
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| 2. Round | 04/09/2021 | Extremadura UD | - | SD Logroñés | 0:0 | ||||
| 3. Round | 12/09/2021 | Unionistas CF | - | Extremadura UD | 3:0 | |
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| 4. Round | 17/09/2021 | Extremadura UD | - | Racing Ferrol | 1:0 | ||||
| 5. Round | 26/09/2021 | Extremadura UD | - | Rayo Majadahonda | 3:2 | ||||
| 6. Round | 03/10/2021 | CF Talavera | - | Extremadura UD | 1:1 | ||||
| 7. Round | 09/10/2021 | Extremadura UD | - | Real Valladolid B | 1:0 | ||||
| 8. Round | 16/10/2021 | Cultural Leonesa | - | Extremadura UD | 2:1 | ||||
| 9. Round | 22/10/2021 | Extremadura UD | - | CD Tudelano | 1:1 | ||||
| 10. Round | 30/10/2021 | CD Badajoz | - | Extremadura UD | 2:0 | ||||
| 11. Round | 07/11/2021 | Extremadura UD | - | Inter de Madrid | 1:2 | ||||
| 13. Round | 20/11/2021 | Extremadura UD | - | CD Calahorra | 0:2 | ||||
| 14. Round | 28/11/2021 | RC Celta B | - | Extremadura UD | 1:1 | ||||
| 15. Round | 04/12/2021 | Extremadura UD | - | Zamora CF | 2:2 | ||||
| 16. Round | 12/12/2021 | UD Logroñés | - | Extremadura UD | 1:3 | |
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| 17. Round | 18/12/2021 | Extremadura UD | - | Racing Santander | 2:4 |
Spain