| 1. Round | 14/08/2021 | RWD Molenbeek | - | Royal Excel Mouscron | 3:1 | ||||
| 2. Round | 20/08/2021 | KVC Westerlo | - | RWD Molenbeek | 0:0 | ||||
| 3. Round | 27/08/2021 | RWD Molenbeek | - | Excelsior Virton | 0:0 | ||||
| 4. Round | 12/09/2021 | Lierse Kempenzonen | - | RWD Molenbeek | 4:1 | ||||
| 8. Round | 17/10/2021 | RWD Molenbeek | - | KVC Westerlo | 1:2 | ||||
| 9. Round | 22/10/2021 | Royal Excel Mouscron | - | RWD Molenbeek | 1:1 | ||||
| 10. Round | 31/10/2021 | Lommel SK | - | RWD Molenbeek | 2:3 | ||||
| 11. Round | 07/11/2021 | RWD Molenbeek | - | Lierse Kempenzonen | 3:3 | ||||
| 12. Round | 21/11/2021 | Excelsior Virton | - | RWD Molenbeek | 0:2 | ||||
| 13. Round | 28/11/2021 | RWD Molenbeek | - | KMSK Deinze | 2:2 | ||||
| 14. Round | 04/12/2021 | Waasland-Beveren | - | RWD Molenbeek | 2:3 | ||||
| 16. Round | 19/12/2021 | Lierse Kempenzonen | - | RWD Molenbeek | 0:1 | ||||
| 17. Round | 21/01/2022 | RWD Molenbeek | - | Lommel SK | 2:0 | ||||
| 15. Round | 25/01/2022 | RWD Molenbeek | - | KVC Westerlo | 0:2 | ||||
| 19. Round | 06/02/2022 | Excelsior Virton | - | RWD Molenbeek | 0:1 | ||||
| 24. Round | 12/03/2022 | Lommel SK | - | RWD Molenbeek | 0:0 | ||||
| 25. Round | 20/03/2022 | RWD Molenbeek | - | Excelsior Virton | 3:0 |
Belgium
Congo