| 2. Round | 24/08/2021 | Marumo Gallants | - | Orlando Pirates | 0:0 | ||||
| 3. Round | 11/09/2021 | Orlando Pirates | - | Moroka Swallows | 1:0 |  |
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| 4. Round | 18/09/2021 | Chippa United | - | Orlando Pirates | 1:3 | |
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| 5. Round | 25/09/2021 | Orlando Pirates | - | Mamelodi Sundowns | 0:2 | ||||
| 6. Round | 02/10/2021 | Cape Town City FC | - | Orlando Pirates | 1:1 | ||||
| 7. Round | 20/10/2021 | Maritzburg United | - | Orlando Pirates | 0:0 | ||||
| 8. Round | 28/10/2021 | Orlando Pirates | - | Royal AM | 1:1 |  |
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| 9. Round | 02/11/2021 | Orlando Pirates | - | Sekhukhune United | 2:1 | ||||
| 10. Round | 06/11/2021 | Kaizer Chiefs | - | Orlando Pirates | 2:1 | ||||
| 13. Round | 02/12/2021 | Orlando Pirates | - | Baroka FC | 0:0 | ||||
| 15. Round | 11/12/2021 | Orlando Pirates | - | TS Galaxy | 2:0 | |
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| 21. Round | 05/03/2022 | Orlando Pirates | - | Kaizer Chiefs | 1:2 | ||||
| 24. Round | 06/04/2022 | Sekhukhune United | - | Orlando Pirates | 0:1 | ||||
| 25. Round | 12/04/2022 | Baroka FC | - | Orlando Pirates | 0:0 | ||||
| 26. Round | 27/04/2022 | Orlando Pirates | - | Chippa United | 0:0 | ||||
| 29. Round | 24/05/2022 | Orlando Pirates | - | Maritzburg United | 4:1 | ||||
| 30. Round | 30/05/2022 | SuperSport United | - | Orlando Pirates | 2:0 |
South Africa