| 1. Round | 20/08/2021 | Mamelodi Sundowns | - | AmaZulu FC | 1:0 | ||||
| 3. Round | 14/09/2021 | AmaZulu FC | - | SuperSport United | 0:0 | ||||
| 5. Round | 25/09/2021 | AmaZulu FC | - | Baroka FC | 1:0 | ||||
| 8. Round | 27/10/2021 | Sekhukhune United | - | AmaZulu FC | 2:0 | ||||
| 12. Round | 28/11/2021 | Maritzburg United | - | AmaZulu FC | 1:1 | ||||
| 13. Round | 04/12/2021 | AmaZulu FC | - | Royal AM | 0:0 | ||||
| 14. Round | 08/12/2021 | AmaZulu FC | - | Orlando Pirates | 1:1 |  |
|||
| 22. Round | 14/12/2021 | AmaZulu FC | - | Chippa United | 2:2 | ||||
| 16. Round | 17/12/2021 | Marumo Gallants | - | AmaZulu FC | 0:1 | ||||
| 20. Round | 02/03/2022 | AmaZulu FC | - | Stellenbosch FC | 2:2 | ||||
| 21. Round | 05/03/2022 | SuperSport United | - | AmaZulu FC | 2:0 | ||||
| 25. Round | 16/04/2022 | AmaZulu FC | - | Maritzburg United | 1:0 | ||||
| 28. Round | 07/05/2022 | AmaZulu FC | - | Sekhukhune United | 0:0 |
South Africa