| 1. Round | 16/07/2021 | Sepsi OSK | - | Academica Clinceni | 2:0 | ||||
| 3. Round | 02/08/2021 | Sepsi OSK | - | CS Mioveni | 1:2 |  |
|||
| 4. Round | 09/08/2021 | Farul Constanța | - | Sepsi OSK | 1:0 | ||||
| 5. Round | 15/08/2021 | Sepsi OSK | - | Argeș Pitești | 0:2 | ||||
| 6. Round | 23/08/2021 | FCSB | - | Sepsi OSK | 1:1 | ||||
| 7. Round | 29/08/2021 | Sepsi OSK | - | FC Botoşani | 1:1 | ||||
| 8. Round | 13/09/2021 | CS Universitatea Craiova | - | Sepsi OSK | 1:1 | ||||
| 9. Round | 19/09/2021 | Sepsi OSK | - | UTA Arad | 0:0 | ||||
| 10. Round | 27/09/2021 | Gaz Metan Mediaş | - | Sepsi OSK | 0:0 | ||||
| 11. Round | 02/10/2021 | Sepsi OSK | - | Rapid Bucureşti | 2:2 | ||||
| 12. Round | 16/10/2021 | Sepsi OSK | - | FC Voluntari | 1:2 | ||||
| 13. Round | 25/10/2021 | CFR Cluj | - | Sepsi OSK | 2:0 | ||||
| 14. Round | 31/10/2021 | Sepsi OSK | - | Dinamo Bucureşti | 4:1 | ||||
| 15. Round | 06/11/2021 | FC Universitatea Craiova | - | Sepsi OSK | 1:1 | ||||
| 16. Round | 19/11/2021 | Academica Clinceni | - | Sepsi OSK | 0:2 |  |
|||
| 17. Round | 27/11/2021 | Sepsi OSK | - | Chindia Târgoviște | 0:0 | |
|||
| 18. Round | 05/12/2021 | CS Mioveni | - | Sepsi OSK | 0:2 | ||||
| 19. Round | 12/12/2021 | Sepsi OSK | - | Farul Constanța | 1:0 | ||||
| 20. Round | 15/12/2021 | Argeș Pitești | - | Sepsi OSK | 1:1 |
Bulgaria