| 14. Round | 20/11/2021 | Barry Town United | - | Cefn Druids | 1:0 | ||||
| 15. Round | 04/12/2021 | Cefn Druids | - | Cardiff Metropolitan | 1:3 | ||||
| 16. Round | 11/12/2021 | Penybont FC | - | Cefn Druids | 7:1 | ||||
| 17. Round | 17/12/2021 | Cefn Druids | - | Bala Town | 3:5 | ||||
| 20. Round | 21/01/2022 | Cefn Druids | - | Caernarfon Town | 1:3 | ||||
| 22. Round | 26/02/2022 | Cefn Druids | - | Haverfordwest County | 0:2 |
England