| 1. Round | 08/08/2020 | FK Senica | - | MŠK Žilina | 0:4 |  |
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| 2. Round | 11/08/2020 | MŠK Žilina | - | FC Nitra | 1:2 | |
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| 3. Round | 15/08/2020 | AS Trenčín | - | MŠK Žilina | 2:4 | |
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| 4. Round | 22/08/2020 | FK Pohronie | - | MŠK Žilina | 2:1 | ||||
| 5. Round | 30/08/2020 | MŠK Žilina | - | MFK Zemplín Michalovce | 6:2 | |
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| 6. Round | 12/09/2020 | ŠKF Sereď | - | MŠK Žilina | 3:2 | ||||
| 8. Round | 26/09/2020 | Zlaté Moravce | - | MŠK Žilina | 4:0 | ||||
| 9. Round | 03/10/2020 | MŠK Žilina | - | FC DAC 1904 | 4:1 | |
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| 10. Round | 18/10/2020 | MŠK Žilina | - | Spartak Trnava | 2:1 | |
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| 11. Round | 24/10/2020 | MFK Ružomberok | - | MŠK Žilina | 2:1 | ||||
| 12. Round | 31/10/2020 | MŠK Žilina | - | FK Senica | 3:1 | |
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| 13. Round | 08/11/2020 | FC Nitra | - | MŠK Žilina | 0:3 | |
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| 16. Round | 05/12/2020 | MFK Zemplín Michalovce | - | MŠK Žilina | 1:1 | ||||
| 17. Round | 12/12/2020 | MŠK Žilina | - | ŠKF Sereď | 0:0 | ||||
| 18. Round | 16/12/2020 | Slovan Bratislava | - | MŠK Žilina | 3:2 |  |
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| 19. Round | 13/02/2021 | MŠK Žilina | - | Zlaté Moravce | 4:1 | ||||
| 20. Round | 21/02/2021 | FC DAC 1904 | - | MŠK Žilina | 1:1 | ||||
| 21. Round | 27/02/2021 | Spartak Trnava | - | MŠK Žilina | 2:1 | ||||
| 22. Round | 06/03/2021 | MŠK Žilina | - | MFK Ružomberok | 3:2 |
Armenia