| Group E | 14/04/2021 | Persepolis | - | Al Wahda | 1:0 | ||||
| Group E | 17/04/2021 | Al Rayyan | - | Persepolis | 1:3 | ||||
| Group E | 20/04/2021 | Persepolis | - | FC Goa | 2:1 | ||||
| Group E | 23/04/2021 | FC Goa | - | Persepolis | 0:4 | ||||
| Group E | 26/04/2021 | Al Wahda | - | Persepolis | 1:0 |  |
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| Group E | 29/04/2021 | Persepolis | - | Al Rayyan | 4:2 | ||||
| Round of 16 | 14/09/2021 | FC Istiklol | - | Persepolis | 0:1 | ||||
| Quarter-finals | 16/10/2021 | Al Hilal | - | Persepolis | 3:0 |
Iran