| Group E | 14/05/2021 | Peñarol | - | Corinthians SP | 4:0 | ||||
| Group E | 18/05/2021 | River Plate | - | Peñarol | 2:1 | ||||
| Group E | 27/05/2021 | Sport Huancayo | - | Peñarol | 0:0 | ||||
| Round of 16 | 16/07/2021 | Nacional | - | Peñarol | 1:2 |  |
 |
||
| Round of 16 | 23/07/2021 | Peñarol | - | Nacional | 0:1 | ||||
| Quarter-finals | 11/08/2021 | Sporting Cristal | - | Peñarol | 1:3 | ||||
| Quarter-finals | 18/08/2021 | Peñarol | - | Sporting Cristal | 1:0 | ||||
| Semi-finals | 24/09/2021 | Peñarol | - | Athletico Paranaense | 1:2 | |
|||
| Semi-finals | 01/10/2021 | Athletico Paranaense | - | Peñarol | 2:0 |
Uruguay