1. Round | 18/07/2021 | Spartak Subotica | - | Radnički Niš | 1:1 | ||||
2. Round | 24/07/2021 | Radnički Niš | - | FK Napredak | 4:2 | ||||
3. Round | 31/07/2021 | Radnik Surdulica | - | Radnički Niš | 1:1 | ||||
4. Round | 09/08/2021 | Radnički Niš | - | TSC Bačka Topola | 1:2 | ||||
5. Round | 15/08/2021 | FK Čukarički | - | Radnički Niš | 0:0 | ||||
6. Round | 23/08/2021 | Radnički Niš | - | Proleter Novi Sad | 0:1 | ||||
7. Round | 29/08/2021 | Partizan | - | Radnički Niš | 4:0 | ||||
8. Round | 12/09/2021 | Radnički Niš | - | FK Voždovac | 1:0 | ||||
11. Round | 25/09/2021 | FK Kolubara | - | Radnički Niš | 2:3 | ||||
10. Round | 30/09/2021 | Radnički Niš | - | FK Metalac | 1:1 | ||||
16. Round | 07/11/2021 | Radnički Niš | - | Spartak Subotica | 0:0 | ||||
17. Round | 20/11/2021 | FK Napredak | - | Radnički Niš | 1:1 | ||||
18. Round | 28/11/2021 | Radnički Niš | - | Radnik Surdulica | 3:0 |