| 1. Round | 08/08/2021 | Sporting San Miguelito | - | Alianza | 1:2 | ||||
| 2. Round | 15/08/2021 | Plaza Amador | - | Sporting San Miguelito | 0:0 | ||||
| 3. Round | 21/08/2021 | Sporting San Miguelito | - | Tauro FC | 1:0 | ||||
| 7. Round | 17/09/2021 | Independiente de La Chorrera | - | Sporting San Miguelito | 3:0 | ||||
| 8. Round | 26/09/2021 | Veraguas Club Deportivo | - | Sporting San Miguelito | 2:0 | ||||
| 9. Round | 03/10/2021 | Sporting San Miguelito | - | Herrera FC | 1:1 | ||||
| 10. Round | 10/10/2021 | Sporting San Miguelito | - | San Francisco FC | 1:1 |
Paraguay