| 1. Round | 18/07/2021 | Sport Huancayo | - | FBC Melgar | 0:3 |  |
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| 2. Round | 24/07/2021 | Alianza Atlético | - | Sport Huancayo | 1:0 | ||||
| 3. Round | 31/07/2021 | Sport Huancayo | - | Universidad Técnica | 0:0 | ||||
| 5. Round | 06/08/2021 | Sport Huancayo | - | Sporting Cristal | 1:2 | ||||
| 6. Round | 15/08/2021 | Cienciano | - | Sport Huancayo | 0:0 | ||||
| 7. Round | 18/08/2021 | Sport Huancayo | - | Ayacucho FC | 1:1 | ||||
| 8. Round | 23/08/2021 | Alianza Lima | - | Sport Huancayo | 1:1 | ||||
| 9. Round | 29/08/2021 | Sport Huancayo | - | Sport Boys | 1:1 | ||||
| 10. Round | 11/09/2021 | Academia Cantolao | - | Sport Huancayo | 0:0 | ||||
| 11. Round | 19/09/2021 | Sport Huancayo | - | Universidad San Martín | 3:1 |  |
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| 12. Round | 23/09/2021 | Deportivo Municipal | - | Sport Huancayo | 2:2 | ||||
| 13. Round | 26/09/2021 | Sport Huancayo | - | Universitario de Deportes | 1:3 | ||||
| 14. Round | 02/10/2021 | Sport Huancayo | - | Alianza Universidad | 4:3 | ||||
| 15. Round | 18/10/2021 | Universidad Cesar Vallejo | - | Sport Huancayo | 0:0 | ||||
| 16. Round | 23/10/2021 | Sport Huancayo | - | Deportivo Binacional | 2:0 |
Peru