2. Round | 23/01/2021 | Independiente Medellín | - | Patriotas FC | 2:1 | ||||
3. Round | 01/02/2021 | Atlético Bucaramanga | - | Independiente Medellín | 0:1 | ||||
4. Round | 05/02/2021 | Independiente Medellín | - | Millonarios | 0:0 | ||||
5. Round | 07/02/2021 | Deportes Tolima | - | Independiente Medellín | 2:1 | ||||
6. Round | 14/02/2021 | Independiente Medellín | - | Jaguares de Córdoba | 1:0 | ||||
12. Round | 14/03/2021 | Águilas Doradas | - | Independiente Medellín | 0:2 | ||||
15. Round | 28/03/2021 | Independiente Medellín | - | Atlético Nacional | 0:0 | ||||
17. Round | 07/04/2021 | Deportivo Pereira | - | Independiente Medellín | 1:0 | ||||
18. Round | 10/04/2021 | Independiente Medellín | - | Alianza Petrolera | 2:2 | ||||
19. Round | 18/04/2021 | Once Caldas | - | Independiente Medellín | 2:0 |